Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4
نویسندگان
چکیده
منابع مشابه
Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4.
Proteinases and the innate immune receptor Toll-like receptor 4 (TLR4) are essential for expression of allergic inflammation and diseases such as asthma. A mechanism that links these inflammatory mediators is essential for explaining the fundamental basis of allergic disease but has been elusive. Here, we demonstrate that TLR4 is activated by airway proteinase activity to initiate both allergic...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2001
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.167.5.2887